Not enough info to make an informed choice. Questions: TPD2EUSB30DRTR: What data rate are you working at? What version of USB (3 or lower)? NC7WZ16P6X: What frequency or data rate is the "audio" output? What load do you have to drive? (Impedance/power/current/voltage swing?) Are you driving the load differentially (using 2 devices to make a bridge output)?

Could you not get JLCPCB to assemble your PCBs?

JLCPCB to assemble? JLCPCB dont have most parts in stock. They all seem basic parts that are used on official CM4 IO board. Most parts, connectors are out of stock (eg. DF40C-100DS-0.4V(51))  If I try to find something else then MOQ is 50 or 100. I had to source my parts on my own as JLCPCB wasn't much of a help. USB doesnt have to be 3.0 I think they have just basic outputs. Same what CM4 IO board has.  

@tescojim, "Same what CM4 IO board has." As stated in: [https://easyeda.com/forum/topic/How-to-ask-for-help-and-get-an-answer-71b17a40d15442349eaecbfae083e46a](https://easyeda.com/forum/topic/How-to-ask-for-help-and-get-an-answer-71b17a40d15442349eaecbfae083e46a)<br> <br> please don't assume that everyone knows what a "CM4 IO board" is. Please provide enough information for people to understand the issues and the context so that they can help you without having to spend an hour or so looking for datasheets and device specs..

@tescojim, **Alternative to TPD2EUSB30DRTR:** USBLC6-2: SOT23-6 [https://www.st.com/resource/en/datasheet/usblc6-2.pdf](https://www.st.com/resource/en/datasheet/usblc6-2.pdf)<br> <br> Note however that the TPD2EUSB30DRTR is intended for use with a 5V supply. The TPD2EUSB30**A**DRTR has a 4V zener voltage compared to the TPD2EUSB30DRTR (and hence the USBLC6-2) 6V breakdown. <br> **Alternative to NC7WZ16P6X:** SN74LVC2G34DBV: SOT23-6 [https://www.ti.com/product/SN74LVC2G34](https://www.ti.com/product/SN74LVC2G34?utm_source=google&utm_medium=cpc&utm_campaign=asc-null-null-GPN_EN-cpc-pf-google-eu&utm_content=SN74LVC2G34&ds_k=SN74LVC2G34&DCM=yes&gclid=Cj0KCQjwhLKUBhDiARIsAMaTLnEOhAfukAvtZuuTiD4jS_ZJjG9M8C0WaYx4RTtHv8Pw4vLpN-U9z9QaAtT4EALw_wcB&gclsrc=aw.ds)<br> <br> What are you using the NC7WZ16P6X since you appear to only be using one of it's channels?

Im sorry for not clarifying the specifications of CM4 IO. I use one one channel for a mono speaker. Unfortunately I haven't been able to figure out how to connect a single channel to CM4. (Im not familiar with electronic engineering.) I found a schematic online and tried to add it to my circuitry. I dont quite know hoe these parts work. :(

@tescojim, So if you can post a link to info about whatever this CM4 IO board is and some more background (a short Design Requirements Spec and a clarification of what you want to achieve) then maybe others can offer you more advice to help you. :)