You will find the answer to this question and a lot more in the Simulation Tutorial, (3) in (2) in : [https://easyeda.com/forum/topic/How-to-ask-for-help-and-get-an-answer-71b17a40d15442349eaecbfae083e46a](https://easyeda.com/forum/topic/How-to-ask-for-help-and-get-an-answer-71b17a40d15442349eaecbfae083e46a)

GND at the bottom of R4 does not connect to the net connected to the GND pin on U2. There is no spice model available for the FL5150MX. Other devices that you have chosen may also not have spice models. Your screenshot shows no voltage source as a power supply.